Hixia Custom Synthesis

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Expertise

DNA chips and microarrays technology

Fluorescence Compounds





Our Expertise includes:-

> Heterocyclic systems
> Chemistry and functional group creation / manipulation
> High Pressure Hastalloy Equipment
> Analytical Facilities
> High Pressure Liquid Chromatography
> Mass Spectroscopy

Expertise in a broad range of heterocyclic systems including:

Indoles [2,3,5 and 8 substituted]

Quinolines

Fused and unfused tetrazoles and triazoles

Quinazolines

Pyrimidines

Pyridines

Methylene dioxybenzene derivatives

Furan chemistry



Expertise in the following areas of chemistry and functional group creation / manipulation:

Nitration

Halogenation,

Azide and aza Wittig chemistry

Boronic acids

High pressure phosphorus oxychloride chemistry

Reduction including Pt, Pd

Hydrogenation including use of chiral ligands

Grignard and Lithium chemistry

Phosgenation

Asymmetric synthesis

Dipolar cycloaddition chemistry

Enzymatic chiral resolution including hydrolase, esterase, dehalogenase



Equipment Available:

Manufacturing equipment:

Glass and stainless steel to 50L

Operating temperatures –80 to 300oC

Specialist manufacturing equipment:

High pressure Hastalloy reactors 1-4L max operating pressure 275 barg and –80oC to 300oC

High pressure Stainless steel reactors 1-25L max operating pressure 250 barg and –80oC to 300oC

High pressure Glass reactors 1-3L max operating pressure 5 barg and –80oC to 300oC

High Vacuum distillation equipment 0.01mmHg 50 theoretical plates



Analytical Facilities Available:

Nuclear Magnetic Spectroscopy:

400MHz FT NMR

500 & 600MHz available upon request

Multinuclear Spectroscopy

NOE, cosey



High Pressure Liquid Chromatography:

Mono and binary systems available

HPLC-MS available upon request



Mass Spectroscopy:

C.I. / E.I. /  FAB

MALDI-TOF

The following techniques are also available:

FT-IR

UV-Vis

Karl-Fisher

Polarimeter

Elemental Analysis

Sulphated Ash

GC (including residual solvents)

Atomic absorption

X-Ray crystallography

 
 

DNA microarray (chip) Technology:

Including manufacture of Photo-labile blocking groups

e.g. MeNPOC or [R,S]-1-[3,4-[methylene-dioxy]-6-nitrophenyl] ethyl chloroformate)

Fluorescence Labelling Technology:

Including sialic acid derivatisating agents

e.g.  DMB 1,2-Diamino-4,5-methylenedioxybenzene CAS 818-15-5