Our Expertise includes:-

Indoles [2,3,5 and 8 substituted]

Quinolines

Fused and unfused tetrazoles and triazoles

Quinazolines

Pyrimidines

Pyridines

Methylene dioxybenzene derivatives

Furan chemistry

Nitration

Halogenation,

Azide and aza Wittig chemistry

Boronic acids

High pressure phosphorus oxychloride chemistry

Reduction including Pt, Pd

Hydrogenation including use of chiral ligands

Grignard and Lithium chemistry

Phosgenation

Asymmetric synthesis

Dipolar cycloaddition chemistry

Enzymatic chiral resolution including hydrolase, esterase, dehalogenase

Glass and stainless steel to 50L

Operating temperatures –80 to 300^oC

High pressure Hastalloy reactors 1-4L max operating pressure 275 barg and –80^oC to 300^oC

High pressure Stainless steel reactors 1-25L max operating pressure 250 barg and –80^oC to 300^oC

High pressure Glass reactors 1-3L max operating pressure 5 barg and –80^oC to 300^oC

High Vacuum distillation equipment 0.01mmHg 50 theoretical plates

400MHz FT NMR

500 & 600MHz available upon request

Multinuclear Spectroscopy

NOE, cosey

Mono and binary systems available

HPLC-MS available upon request

C.I. / E.I. /  FAB

MALDI-TOF

FT-IR

UV-Vis

Karl-Fisher

Polarimeter

Elemental Analysis

Sulphated Ash

GC (including residual solvents)

Atomic absorption

X-Ray crystallography

Including manufacture of Photo-labile blocking groups

e.g. MeNPOC or [R,S]-1-[3,4-[methylene-dioxy]-6-nitrophenyl] ethyl chloroformate)

Including sialic acid derivatisating agents

e.g.  DMB 1,2-Diamino-4,5-methylenedioxybenzene CAS 818-15-5